Circulating Neuronatin Levels Are Positively Associated with BMI and Body Fat Mass but Not with Psychological Parameters

Human genetic studies have associated Neuronatin gene variants with anorexia nervosa (AN) and obesity. Studies on the expression of product, a proteolipid, are lacking. We investigated relationship between circulating Neuronatin, body mass index (BMI), composition (BC), physical activity (PA), psychometric outcomes in patients AN, normal weight, Plasma was measured by ELISA (1) 79 subjects five BMI categories (AN/BMI < 17.5 kg/m2; weight/BMI 18.5–25 obesity/BMI 30–40 40–50 > 50 kg/m2) assessment BC (bioimpedance analysis; BIA); (2) 49 women AN (BMI 14.5 ± 1.8 measurements (BIA) PA (accelerometry); (3) obesity 48.8 7.8 anxiety (GAD-7), stress (PSQ-20), depression (PHQ-9) eating behavior (EDI-2). Overall, positive correlation found (p = 0.006) as well total fat (FM; p 0.036). In did not correlate BMI, FM, or 0.05); no correlations were 0.05). The findings suggest an FM-dependent peripheral expression. decreased provides evidence that is implicated pathogenesis disorders.